Article
Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy.
Journal of the American Society of Nephrology : JASN - 1 Nov 2016
Huang Zhi Qiang, Raska Milan, Stewart Tyler J, Reily Colin, King R Glenn, Crossman David K, Crowley Michael R, Hargett Audra, Zhang Zhixin, Suzuki Hitoshi, Hall Stacy, Wyatt Robert J, Julian Bruce A, Renfrow Matthew B, Gharavi Ali G, Novak Jan
Abstract excerpt
Autoantibodies against galactose-deficient IgA1 drive formation of pathogenic immune complexes in IgA nephropathy. IgG autoantibodies against galactose-deficient IgA1 in patients with IgA nephropathy have a specific amino-acid sequence, Y1CS3, in the complementarity-determining region 3 of the heavy chain variable region compared with a Y1CA3 sequence in similar isotype-matched IgG from healthy controls. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.