Article
Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.
Molecular and cellular biology - 1 Jan 2005
Kissenpfennig Adrien, Aït-Yahia Smina, Clair-Moninot Valérie, Stössel Hella, Badell Edgar, Bordat Yann, Pooley Joanne L, Lang Thierry, Prina Eric, Coste Isabelle, Gresser Olivia, Renno Toufic, Winter Nathalie, Milon Geneviève, Shortman Ken, Romani Nikolaus, Lebecque Serge, Malissen Bernard, Saeland Sem, Douillard Patrice
Abstract excerpt
Langerin is a C-type lectin expressed by a subset of dendritic leukocytes, the Langerhans cells (LC). Langerin is a cell surface receptor that induces the formation of an LC-specific organelle, the Birbeck granule (BG). We generated a langerin(-/-) mouse on a C57BL/6 background which did not display any macroscopic aberrant development. In the absence of langerin, LC were detected in normal numbers in the...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Antigens
- Antigens, Surface
- Blastocyst
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Carcinogens
- Cell Movement