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Article

Alteration of the langerin oligomerization state affects Birbeck granule formation.

Biophysical journal - 3 Feb 2015

Chabrol Eric, Thépaut Michel, Dezutter-Dambuyant Colette, Vivès Corinne, Marcoux Julien, Kahn Richard, Valladeau-Guilemond Jenny, Vachette Patrice, Durand Dominique, Fieschi Franck

Abstract excerpt

Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate recognition domains (CRD). In the context of HIV-1 (human immunodeficiency virus-1) transmission, Langerhans cells of genital mucosa play a protective role by internalizing virions in Birbeck Granules (BG) for elimination....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25650933
DOI: 10.1016/j.bpj.2014.10.075
PMCID: PMC4317532

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ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Alteration of the langerin oligomerization state affects Birbeck granule formation.PMID 25650933Read ↗

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Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.Semantic proximity Read ↗

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