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Article

Langerin functions as an antiviral receptor on Langerhans cells

23 Mar 2010

Abstract excerpt

Langerhans cells (LC) are the first dendritic cells (DC) to encounter pathogens entering the body via mucosa or skin. Equipped with pattern recognition receptors (PRR), LC are able to detect and respond to these pathogens. An important PRR, in human exclusively expressed by LC, is the C-type lectin Langerin. Langerin forms a protective barrier against HIV-1 infection by binding and degradation of this virus. In...

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PMID: 20309013
DOI: 10.1038/icb.2010.32

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