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Article

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis.

The Journal of clinical investigation - 1 Nov 2013

Goettsch Claudia, Babelova Andrea, Trummer Olivia, Erben Reinhold G, Rauner Martina, Rammelt Stefan, Weissmann Norbert, Weinberger Valeska, Benkhoff Sebastian, Kampschulte Marian, Obermayer-Pietsch Barbara, Hofbauer Lorenz C, Brandes Ralf P, Schröder Katrin

Abstract excerpt

ROS are implicated in bone diseases. NADPH oxidase 4 (NOX4), a constitutively active enzymatic source of ROS, may contribute to the development of such disorders. Therefore, we studied the role of NOX4 in bone homeostasis. Nox4(-/-) mice displayed higher bone density and reduced numbers and marke...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24216508
DOI: 10.1172/JCI67603
PMCID: PMC3809780

Genes

NOX4
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24216508-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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