Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner.

Scientific reports - 6 Apr 2017

Cong Qian, Jia Hao, Li Ping, Qiu Shoutao, Yeh James, Wang Yibin, Zhang Zhen-Lin, Ao Junping, Li Baojie, Liu Huijuan

Abstract excerpt

Bone mass is determined by the balance between bone formation, carried out by mesenchymal stem cell-derived osteoblasts, and bone resorption, carried out by monocyte-derived osteoclasts. Here we investigated the potential roles of p38 MAPKs, which are activated by growth factors and cytokines including RANKL and BMPs, in osteoclastogenesis and bone resorption by ablating p38α MAPK in LysM+monocytes. p38α...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 2
Share to Bone Remodeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Resorption

Share to Cyclic AMP Response Element-Binding Protein

Share to Integrases

Share to Osteoclasts

Share to Platelet-Derived Growth Factor

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 28382965
DOI: 10.1038/srep45964
PMCID: PMC5382695

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner.PMID 28382965Read ↗

CD11B <sup>+</sup> CD36 <sup>+</sup> cells are bone anabolic macrophages that limit age-associated bone lossSemantic proximity Read ↗

Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice.Semantic proximity Read ↗

p38 MAPK Signaling in Osteoblast DifferentiationSemantic proximity Read ↗

Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPKSemantic proximity Read ↗

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone HomeostasisSemantic proximity Read ↗

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in miceSemantic proximity Read ↗

Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation.Semantic proximity Read ↗

Activating transcription factor 4 regulates osteoclast differentiation in miceSemantic proximity Read ↗

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis.Semantic proximity Read ↗

LRP1 Suppresses Bone Resorption in Mice by Inhibiting the RANKL-Stimulated NF-κB and p38 Pathways During Osteoclastogenesis.Semantic proximity Read ↗

Monocyte Subsets with High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8Semantic proximity Read ↗

Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.