Article

Nox4 Mediates RANKL-induced ER-Phagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway

2020-06-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear. <bold>Methods:</bold> Osteoclastogenesis was evaluated by number of TRAP-positive multinuclear (≥3) osteoclasts, bone resorption pits and expression levels of related genes. Autophagy...

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Literature Corpus work: 56de937a-7055-5fb9-a968-e9aaa05b9872
DOI: 10.21203/rs.3.rs-34288/v1

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