Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic Ethanol Feeding in Mice Decreases Expression of Genes for Major Structural Bone Proteins in a Nox4-Independent Manner.

The Journal of pharmacology and experimental therapeutics - 1 Jun 2020

Pedersen Kim B, Osborn Michelle L, Robertson Alex C, Williams Ashlee E, Watt James, Denys Alexandra, Schröder Katrin, Ronis Martin J

Abstract excerpt

Bone loss in response to alcohol intake has previously been hypothesized to be mediated by excessive production of reactive oxygen species via NADPH oxidase (Nox) enzymes. Nox4 is one of several Nox enzymes expressed in bone. We investigated the role of Nox4 in the chondro-osteoblastic lineage of the long bones in mice during normal chow feeding and during chronic ethanol feeding for 90 days. We generated mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanol

Share to NADPH Oxidases

Share to Osteoblasts

Share to Oxidation-Reduction

Share to Oxidative Stress

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 32213546
DOI: 10.1124/jpet.119.264374
PMCID: PMC7228502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic Ethanol Feeding in Mice Decreases Expression of Genes for Major Structural Bone Proteins in a Nox4-Independent Manner.PMID 32213546Read ↗

Loss of functional NADPH oxidase 2 protects against alcohol-induced bone resorption in female p47phox-/- mice.Semantic proximity Read ↗

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis.Semantic proximity Read ↗

Bone disorders: targeting NOX4 knocks down osteoporosis.Semantic proximity Read ↗

Sexually dimorphic effects of prenatal alcohol exposure on the murine skeletonSemantic proximity Read ↗

Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development.Semantic proximity Read ↗

Genetically modified animal models as tools for studying bone and mineral metabolism.Semantic proximity Read ↗

Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck.Semantic proximity Read ↗

A mutation in the ZNF687 gene that is responsible for the severe form of Paget’s disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse modelSemantic proximity Read ↗

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.Semantic proximity Read ↗

Postnatal growth restriction and gene expression changes in a mouse model of fetal alcohol syndrome.Semantic proximity Read ↗

Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiencySemantic proximity Read ↗

Long-Term Modulations in the Vertebral Transcriptome of Adolescent-Stage Rats Exposed to Binge AlcoholSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.