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Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass

4 Jun 2020

Abstract excerpt

Osteoporosis is a genetic disease characterized by progressive reductions in bone mineral density (BMD) leading to an increased risk of fracture. Over the last decade, genome-wide association studies (GWASs) have identified over 1000 associations for BMD. However, as a phenotype BMD is challenging as bone is a multicellular tissue affected by both local and systemic physiology. Here, we focused on a single...

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PMID: 32497039
DOI: 10.1371/journal.pgen.1008805

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