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Article

Loss of functional NADPH oxidase 2 protects against alcohol-induced bone resorption in female p47phox-/- mice.

Alcoholism, clinical and experimental research - 1 Mar 2014

Mercer Kelly E, Sims Clark R, Yang Carrie S, Wynne Rebecca A, Moutos Christopher, Hogue William R, Lumpkin Charles K, Suva Larry J, Chen Jin-Ran, Badger Thomas M, Ronis Martin J J

Abstract excerpt

BACKGROUND: In bone, NADPH oxidase (NOX)-derived reactive oxygen species (ROS) superoxide and/or hydrogen peroxide are an important stimulus for osteoclast differentiation and activity. Previously, we have demonstrated that chronic ethanol (EtOH) consumption generates excess NOX-dependent ROS in...

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Identifiers

PMID: 24256560
DOI: 10.1111/acer.12305
PMCID: PMC4068959

Genes

NOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24256560-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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