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Article

Mechanisms of HBV-induced hepatocellular carcinoma.

Journal of hepatology - 1 Apr 2016

Levrero Massimo, Zucman-Rossi Jessica

Abstract excerpt

Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early steps of clonal tumor expansion and induces both genomic instability and direct insertional mutagenesis of diverse cancer-related genes. Prolonged expression of the viral regulatory protein HBx and/or altered versions of the preS/S...

Topics

Carcinoma, Hepatocellular
Cell Transformation, Neoplastic
DNA, Neoplasm
DNA, Viral
Hepatitis B
Hepatitis B virus
Hepatocytes
Humans
Liver Neoplasms
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27084040
DOI: 10.1016/j.jhep.2016.02.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27084040-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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