Article
Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish.
PloS one - 1 Jan 2013
Lu Jeng-Wei, Yang Wan-Yu, Tsai Su-Mei, Lin Yueh-Min, Chang Pen-Heng, Chen Jim-Ray, Wang Horng-Dar, Wu Jen-Leih, Jin Shiow-Lian Catherine, Yuh Chiou-Hwa
Abstract excerpt
Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to fibrosis and, finally, into cancer. Many etiological factors, including hepatitis B virus X antigen (HBx) and p53 mutations, have been implicated in hepatocarcinogenesis. However, potential synergistic effects between these two factors and the underlying mechanisms by which they promote hepatocarcinogenesis are still...
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