Article
SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort.
PloS one - 1 Jan 2012
Thun Gian-Andri, Ferrarotti Ilaria, Imboden Medea, Rochat Thierry, Gerbase Margaret, Kronenberg Florian, Bridevaux Pierre-Olivier, Zemp Elisabeth, Zorzetto Michele, Ottaviani Stefania, Russi Erich W, Luisetti Maurizio, Probst-Hensch Nicole M
Abstract excerpt
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of respiratory health remains controversial. There is indication from experimental studies that pro-inflammatory agents like cigarette smoke can interact with these variants and thus increase the risk of adverse...
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