Article
SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrations.
Clinical chemistry - 1 Aug 2008
Zorzetto Michele, Russi Erich, Senn Oliver, Imboden Medea, Ferrarotti Ilaria, Tinelli Carmine, Campo Ilaria, Ottaviani Stefania, Scabini Roberta, von Eckardstein Arnold, Berger Wolfgang, Brändli Otto, Rochat Thierry, Luisetti Maurizio, Probst-Hensch Nicole
Abstract excerpt
BACKGROUND: Individuals with severe deficiency in serum alpha(1)-antitrypsin (AAT) concentrations are at high risk for developing chronic obstructive pulmonary disease (COPD), whereas those carrying the PI*MZ genotype are at slightly increased risk. Testing appropriate subgroups of the population for AAT deficiency (AATD) is therefore an important aspect of COPD prevention and timely treatment. We decided to...
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