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Article

Alpha-1 antitrypsin deficiency: From the lung to the heart?

Atherosclerosis - 1 Mar 2018

Curjuric Ivan, Imboden Medea, Bettschart Robert, Caviezel Seraina, Dratva Julia, Pons Marco, Rothe Thomas, Schmidt-Trucksäss Arno, Stolz Daiana, Thun Gian Andri, von Eckardstein Arnold, Kronenberg Florian, Ferrarotti Ilaria, Probst-Hensch Nicole M

Abstract excerpt

BACKGROUND AND AIMS: Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects. In combination with smoking or other long-term noxious exposures such as occupational dust and fumes, genetic A1AT deficiency can cause chronic obstructive pulmonary disease, a condition with elevated cardiovascular risk. The effects of...

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Source

Identifiers

PMID: 29432934
DOI: 10.1016/j.atherosclerosis.2018.01.042

Genes

SERPINA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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