Article
Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels.
The Journal of allergy and clinical immunology - 1 Dec 2015
de Jong Kim, Vonk Judith M, Timens Wim, Bossé Yohan, Sin Don D, Hao Ke, Kromhout Hans, Vermeulen Roel, Postma Dirkje S, Boezen H Marike
Abstract excerpt
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by impaired lung function and airway obstruction resulting from interactions between multiple genes and multiple environmental exposures. Thus far, genome-wide association studies have largely disregarded environmental factors that might trigger the development of lung function impairment and COPD, such as occupational...
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