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Article

Beyond Genetics: What Causes Type 1 Diabetes.

Clinical reviews in allergy & immunology - 1 Apr 2017

Wang Zhen, Xie Zhiguo, Lu Qianjin, Chang Christopher, Zhou Zhiguang

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease resulting from T cell-mediated β cell destruction in the pancreas of genetically susceptible individuals. Extensive familial and population genetic studies uncovered the strong linkage and association between HLA gene variants and T1D. Non-HLA genes have also been associated with T1D, such as INS, CTLA4, and PTPN22. T1D is considered as one of the most heritable...

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Topics

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Share to Diabetes Mellitus, Type 1
Share to Epigenesis, Genetic
Share to CTLA4 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to FOXP3 gene

Share to INS gene

Share to PTPN22 gene

Share to Genetic Predisposition to Disease

Source

Identifiers

PMID: 27878451
DOI: 10.1007/s12016-016-8592-1

Genes

CTLA4
INS
FOXP3
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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