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Article

Sildenafil citrate increases fetal weight in a mouse model of fetal growth restriction with a normal vascular phenotype.

PloS one - 1 Jan 2013

Dilworth Mark Robert, Andersson Irene, Renshall Lewis James, Cowley Elizabeth, Baker Philip, Greenwood Susan, Sibley Colin Peter, Wareing Mark

Abstract excerpt

Fetal growth restriction (FGR) is defined as the inability of a fetus to achieve its genetic growth potential and is associated with a significantly increased risk of morbidity and mortality. Clinically, FGR is diagnosed as a fetus falling below the 5(th) centile of customised growth charts. Sildenafil citrate (SC, Viagra™), a potent and selective phosphodiesterase-5 inhibitor, corrects ex vivo placental vascular...

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Source

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Identifiers

PMID: 24204949
DOI: 10.1371/journal.pone.0077748
PMCID: PMC3813774

Genes

FGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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