Article
Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks.
Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2004
Henderson Kiersten A, Keeney Scott
Abstract excerpt
During meiosis, homologous chromosomes recombine and become closely apposed along their lengths within the synaptonemal complex (SC). In part because Spo11 is required both to make the double-strand breaks (DSBs) that initiate recombination and to promote normal SC formation in many organisms, it is clear that these two processes are intimately coupled. The molecular nature of this linkage is not well understood,...
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