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Article

Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication.

Science (New York, N.Y.) - 2 Feb 2007

Han Junhong, Zhou Hui, Horazdovsky Bruce, Zhang Kangling, Xu Rui-Ming, Zhang Zhiguo

Abstract excerpt

Acetylation of histone H3 lysine 56 (H3-K56) occurs in S phase, and cells lacking H3-K56 acetylation are sensitive to DNA-damaging agents. However, the histone acetyltransferase (HAT) that catalyzes global H3-K56 acetylation has not been found. Here we show that regulation of Ty1 transposition gene product 109 (Rtt109) is an H3-K56 HAT. Cells lacking Rtt109 or expressing rtt109 mutants with alterations at a...

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Identifiers

PMID: 17272723
DOI: 10.1126/science.1133234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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