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Article

Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell.

Digestive diseases and sciences - 1 Mar 2014

Donnelly Jessica M, Engevik Amy C, Engevik Melinda, Schumacher Michael A, Xiao Chang, Yang Li, Worrell Roger T, Zavros Yana

Abstract excerpt

BACKGROUND: Bone marrow-derived mesenchymal stem cells (BM-MSCs) promote gastric cancer in response to gastritis. In culture, BM-MSCs are prone to mutation with continued passage but it is unknown whether a similar process occurs in vivo in response to gastritis. AIM: The purpose of this study was to identify the role of chronic gastritis in the transformation of BM-MSCs leading to an activated cancer-promoting...

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Source

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Identifiers

PMID: 24202649
DOI: 10.1007/s10620-013-2927-z
PMCID: PMC4301577

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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