Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estradiol as a mechanism for sex differences in the development of an addicted phenotype following extended access cocaine self-administration.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2013

Ramôa Carolina P, Doyle Susan E, Naim Diana W, Lynch Wendy J

Abstract excerpt

Women progress more rapidly after initial cocaine use to addiction as compared with men. Similarly, female rats appear to require less cocaine exposure before developing an addicted phenotype with evidence implicating estradiol as a potential mechanism. The goals of this study were to determine whether there are sex differences in the magnitude of the addicted phenotype under optimized conditions that induce its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Addictive
Share to Cocaine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Operant

Share to Hormone Replacement Therapy

Share to Injections, Subcutaneous

Share to Motivation

Share to Ovariectomy

Share to Self Administration

Source

Open in PubMed Open full text

Identifiers

PMID: 23481437
DOI: 10.1038/npp.2013.68
PMCID: PMC3717535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estradiol as a mechanism for sex differences in the development of an addicted phenotype following extended access cocaine self-administration.PMID 23481437Read ↗

Diminished role of dopamine D1-receptor signaling with the development of an addicted phenotype in rats.Semantic proximity Read ↗

Sex Chromosome Complement and Estradiol Modify Cocaine Self-Administration Behaviors in Male Mice.Semantic proximity Read ↗

Females develop features of an addiction-like phenotype sooner during withdrawal than males.Semantic proximity Read ↗

Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine.Semantic proximity Read ↗

Why are women from Venus and men from Mars when they abuse cocaine?Semantic proximity Read ↗

Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences.Semantic proximity Read ↗

Extinction to amphetamine-associated context in female rats is dependent upon conditioned orienting.Semantic proximity Read ↗

Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaineSemantic proximity Read ↗

Sex Differences in Psychostimulant Abuse: Implications for Estrogen Receptors and Histone DeacetylasesSemantic proximity Read ↗

Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats.Semantic proximity Read ↗

On the early-life origins of vulnerability to opioid addictionSemantic proximity Read ↗

High Incidence of Estrous Cycle Irregularities in Heterogeneous Stock (HS) Rats is Associated with Severe Cocaine Addiction-like BehaviorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.