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Article

Spontaneous eosinophilic nasal inflammation in a genetically-mutant mouse: comparative study with an allergic inflammation model.

PloS one - 1 Jan 2012

Cho Seok Hyun, Oh Sun Young, Zhu Zhou, Lee Joan, Lane Andrew P

Abstract excerpt

BACKGROUND: Eosinophilic inflammation is a hallmark of chronic rhinosinusitis with nasal polyps. To model this disease process experimentally, nasal sensitization of mice with ovalbumin or aspergillus has been described. Here, we describe a genetically mutant mouse that develops robust spontaneous nasal eosinophilic inflammation. These mice lack the enzyme SHP-1 that down-regulates the IL-4Rα/stat6 signaling...

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Source

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Identifiers

PMID: 22509389
DOI: 10.1371/journal.pone.0035114
PMCID: PMC3324406

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Source receipt: pubmed, retrieved 7 Sept 2026.

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