Article
Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice.
American journal of physiology. Lung cellular and molecular physiology - 15 Jan 2012
Yao Xianglan, Dai Cuilian, Fredriksson Karin, Lam Jonathan, Gao Meixia, Keeran Karen J, Nugent Gayle Zywicke, Qu Xuan, Yu Zu-Xi, Jeffries Neal, Lin JingPing, Kaler Maryann, Shamburek Robert, Costello Rene, Csako Gyorgy, Dahl Morten, Nordestgaard Børge G, Remaley Alan T, Levine Stewart J
Abstract excerpt
Apolipoprotein E (apoE) is an endogenous negative regulator of airway hyperreactivity (AHR) and mucous cell metaplasia in experimental models of house dust mite (HDM)-induced airway disease. The gene encoding human apoE is polymorphic, with three common alleles (ε2, ε3, and ε4) reflecting single amino acid substitutions at amino acids 112 and 158. The objective of this study was to assess whether the human apoE...
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