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Article

Strand invasion by HLTF as a mechanism for template switch in fork rescue

5 Nov 2013

Abstract excerpt

Stalling of replication forks at unrepaired DNA lesions can result in discontinuities opposite the damage in the newly synthesized DNA strand. Translesion synthesis or facilitating the copy from the newly synthesized strand of the sister duplex by template switching can overcome such discontinuities. During template switch, a new primer-template junction has to be formed and two mechanisms, including replication...

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PMID: 24198246
DOI: 10.1093/nar/gkt1040

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