Article
A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells.
Nature - 1 Jan 2000
Beam K G, Knudson C M, Powell J A
Abstract excerpt
Contraction of a vertebrate skeletal muscle fibre is triggered by electrical depolarization of sarcolemmal infoldings termed transverse-tubules (t-tubules), which in turn causes the release of calcium from an internal store, the sarcoplasmic reticulum (SR). The mechanism that links t-tubular depolarization to SR calcium release remains poorly understood. In principle, this link might be provided by the prominent...
Topics
- Animals
- Calcium
- Genes, Lethal
- Ion Channels
- Membrane Potentials
- Mice
- Muscle Contraction
- Muscles
- Mutation
- Neurons
- Sarcoplasmic Reticulum
- Sodium