Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A transgenic mouse model of the slow-channel syndrome.

Muscle & nerve - 1 Jan 1996

Gomez C M, Bhattacharyya B B, Charnet P, Day J W, Labarca C, Wollmann R L, Lambert E H

Abstract excerpt

To investigate the effect of acetylcholine receptor (AChR) mutations on neuromuscular transmission and to develop a model for the human neuromuscular disease, the slow-channel syndrome, we generated transgenic mice with abnormal AChRs using a delta subunit with a mutation in the ion channel domain. In three transgenic lines, nerve-evoked end-plate currents and spontaneous miniature end-plate currents (MEPCs) had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Gene Expression
Share to Ion Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutation

Share to Patch-Clamp Techniques

Share to Xenopus laevis

Source

Identifiers

PMID: 8538674
DOI: 10.1002/(SICI)1097-4598(199601)19:1<79::AID-MUS11>3.0.CO;2-Z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A transgenic mouse model of the slow-channel syndrome.PMID 8538674Read ↗

Slow-Channel Transgenic Mice: A Model of Postsynaptic Organellar Degeneration at the Neuromuscular JunctionSemantic proximity Read ↗

Active calcium accumulation underlies severe weakness in a panel of mice with slow-channel syndrome.Semantic proximity Read ↗

A mouse model of the slow channel myasthenic syndrome: Neuromuscular physiology and effects of ephedrine treatment.Semantic proximity Read ↗

A new mouse model for the slow-channel congenital myasthenic syndrome induced by the AChR εL221F mutation.Semantic proximity Read ↗

A mouse model of AChR deficiency syndrome with a phenotype reflecting the human condition.Semantic proximity Read ↗

Ion channel mutations in mouse models of inherited neurological disease.Semantic proximity Read ↗

A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells.Semantic proximity Read ↗

Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociation.Semantic proximity Read ↗

Novel delta subunit mutation in slow‐channel syndrome causes severe weakness by novel mechanismsSemantic proximity Read ↗

A beta-subunit mutation in the acetylcholine receptor channel gate causes severe slow-channel syndrome.Semantic proximity Read ↗

Conditional Knockout of Striatal Gnal Produces Dystonia-like Motor PhenotypesSemantic proximity Read ↗

Mouse Model of Fast-Channel Genetic Myasthenic Syndrome Carrying Chrne p.P141L Mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.