Article
A transgenic mouse model of the slow-channel syndrome.
Muscle & nerve - 1 Jan 1996
Gomez C M, Bhattacharyya B B, Charnet P, Day J W, Labarca C, Wollmann R L, Lambert E H
Abstract excerpt
To investigate the effect of acetylcholine receptor (AChR) mutations on neuromuscular transmission and to develop a model for the human neuromuscular disease, the slow-channel syndrome, we generated transgenic mice with abnormal AChRs using a delta subunit with a mutation in the ion channel domai...
Topics
- Animals
- Curare
- Disease Models, Animal
- Electromyography
- Female
- Gene Expression
- Humans
- Ion Channels
- Mice
- Mice, Transgenic
- Motor Endplate
- Mutation
- Neuromuscular Diseases
- Patch-Clamp Techniques
- Receptors, Cholinergic
- Synaptic Transmission
- Xenopus laevis