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Article

Muscular dysgenesis: a model system for studying skeletal muscle development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1990

Powell J A

Abstract excerpt

Muscular dysgenesis, caused by an autosomal recessive lethal mutation (mdg) in mice, is characterized by an absence of contraction of skeletal muscle. A historical review of the investigation of this disorder is presented. The early studies of the morphological and physiological aspects of the disorder in vivo and in vitro presented evidence for dysfunction in the skeletal muscle excitation-contraction (E-C)...

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Identifiers

PMID: 2197156
DOI: 10.1096/fasebj.4.10.2197156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Muscular dysgenesis: a model system for studying skeletal muscle development.PMID 2197156Read ↗

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Early effects in vitro of the muscular dysgenesis mutation on nervous tissue in the mouse.Semantic proximity Read ↗

A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells.Semantic proximity Read ↗

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RyR1-mediated Ca2+-induced Ca2+ release plays a negligible role in excitation-contraction coupling of normal skeletal muscle.Semantic proximity Read ↗

Restoration of dysgenic muscle contraction and calcium channel function by co-culture with normal spinal cord neurons.Semantic proximity Read ↗

Excitation--contraction uncoupling by a human central core disease mutation in the ryanodine receptor.Semantic proximity Read ↗

Neurons induce contractions in myotubes containing only muscular dysgenic nuclei.Semantic proximity Read ↗

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