Article
Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jul 2013
Nelson Benjamin R, Wu Fenfen, Liu Yun, Anderson Douglas M, McAnally John, Lin Weichun, Cannon Stephen C, Bassel-Duby Rhonda, Olson Eric N
Abstract excerpt
Excitation-contraction (EC) coupling comprises events in muscle that convert electrical signals to Ca(2+) transients, which then trigger contraction of the sarcomere. Defects in these processes cause a spectrum of muscle diseases. We report that STAC3, a skeletal muscle-specific protein that localizes to T tubules, is essential for coupling membrane depolarization to Ca(2+) release from the sarcoplasmic reticulum...
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