Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2).

The Journal of biological chemistry - 20 Dec 2013

Matsumura Ritsuko, Matsubara Chiaki, Node Koichi, Takumi Toru, Akashi Makoto

Abstract excerpt

NPAS2 (MOP4) is a heme-containing sensor transcription factor responsive to a wide range of intra- and extracellular stimuli, which also functions as a circadian transcription factor. This molecule forms a heterodimer with another circadian transcription factor, BMAL1, and activates transcription via E-box elements, indicating that circadian phase synchronization between NPAS2 and BMAL1 expression is important...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ARNTL Transcription Factors
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circadian Rhythm

Share to Fibroblasts

Share to NIH 3T3 Cells

Share to Nuclear Receptor Subfamily 1, Group F, Member 1

Share to Response Elements

Share to Transcription Initiation Site

Source

Open in PubMed Open full text

Identifiers

PMID: 24196956
DOI: 10.1074/jbc.M113.517235
PMCID: PMC3868767

Genes

NPAS2
BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2).PMID 24196956Read ↗

The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1.Semantic proximity Read ↗

Roles of NPAS2 in circadian rhythm and disease.Semantic proximity Read ↗

Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and PathologySemantic proximity Read ↗

Unraveling the physiological roles of retinoic acid receptor-related orphan receptor αSemantic proximity Read ↗

The mPer2 gene encodes a functional component of the mammalian circadian clock.Semantic proximity Read ↗

The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes.Semantic proximity Read ↗

Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators.Semantic proximity Read ↗

NPAS2 Contributes to Liver Fibrosis by Direct Transcriptional Activation of Hes1 in Hepatic Stellate CellsSemantic proximity Read ↗

Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogrammingSemantic proximity Read ↗

The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia FactorsSemantic proximity Read ↗

A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes.Semantic proximity Read ↗

Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.