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Article

Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming

9 Oct 2024

Abstract excerpt

Profound functional switch of key regulatory factors may play a major role in homeostasis and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with mechanisms poorly understood. We report here that the function of REV-ERBα, a major CR regulator of the orphan nuclear receptor subfamily, is dramatically altered in tumors in both its genome binding and functional mode. Loss of CR is...

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PMID: 39383000
DOI: 10.1073/pnas.2411321121

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