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Article

A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes.

BMC molecular biology - 4 Jan 2008

Nakahata Yasukazu, Yoshida Mayumi, Takano Atsuko, Soma Haruhiko, Yamamoto Takuro, Yasuda Akio, Nakatsu Toru, Takumi Toru

Abstract excerpt

BACKGROUND: The circadian expression of the mammalian clock genes is based on transcriptional feedback loops. Two basic helix-loop-helix (bHLH) PAS (for Period-Arnt-Sim) domain-containing transcriptional activators, CLOCK and BMAL1, are known to regulate gene expression by interacting with a prom...

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Source

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Identifiers

PMID: 18177499
DOI: 10.1186/1471-2199-9-1
PMCID: PMC2254435

Genes

BMAL1
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18177499-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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