Article
Roles of NPAS2 in circadian rhythm and disease.
Acta biochimica et biophysica Sinica - 12 Oct 2021
Peng L U, Bai Gaigai, Pang Yingxin
Abstract excerpt
NPAS2, a circadian rhythm gene encoding the neuronal PAS domain protein 2 (NPAS2), has received widespread attention because of its complex functions in cells and diverse roles in disease progression, especially tumorigenesis. NPAS2 binds with DNA at E-box sequences and forms heterodimers with another circadian protein, brain and muscle ARNT-like protein 1 (BMAL1). Nucleotide variations of the NPAS2 gene have...
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