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Article

Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7.

The Journal of biological chemistry - 20 Dec 2013

Wu Hsan-au, Balsbaugh Jeremy L, Chandler Hollie, Georgilis Athena, Zullow Hayley, Shabanowitz Jeffrey, Hunt Donald F, Gil Jesus, Peters Gordon, Bernstein Emily

Abstract excerpt

Cbx7 is one of five mammalian orthologs of the Drosophila Polycomb. Cbx7 recognizes methylated lysine residues on the histone H3 tail and contributes to gene silencing in the context of the Polycomb repressive complex 1 (PRC1). However, our knowledge of Cbx7 post-translational modifications remains limited. Through combined biochemical and mass spectrometry approaches, we report a novel phosphorylation site on...

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Identifiers

PMID: 24194518
DOI: 10.1074/jbc.M113.486266
PMCID: PMC3868753

Genes

PRC1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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