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Article

Phosphorylation of CBX2 controls its nucleosome-binding specificity.

Journal of biochemistry - 1 Nov 2017

Kawaguchi Takayuki, Machida Shinichi, Kurumizaka Hitoshi, Tagami Hideaki, Nakayama Jun-Ichi

Abstract excerpt

Chromobox 2 (CBX2), a component of polycomb repressive complex 1 (PRC1), binds lysine 27-methylated histone H3 (H3K27me3) via its chromodomain (CD) and plays a critical role in repressing developmentally regulated genes. The phosphorylation of CBX2 has been described in several studies, but the biological implications of this modification remain largely elusive. Here, we show that CBX2's phosphorylation plays an...

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Source

Identifiers

PMID: 28992316
DOI: 10.1093/jb/mvx040

Genes

CBX2
PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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