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Article

CBX2 suppresses interferon signaling to diminish tumor immunogenicity via a noncanonical corepressor complex

30 Jan 2025

Abstract excerpt

Chromobox 2 (CBX2), a crucial component of the polycomb repressive complex (PRC), has been implicated in the development of various human cancers. However, its role in the regulation of tumor immunogenicity and immune evasion remains inadequately understood. In this study, we found that ablation of CBX2 led to tumor growth inhibition, activation of the tumor immune microenvironment, and enhanced therapeutic...

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PMID: 39883845
DOI: 10.1073/pnas.2417529122

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