Article

Early sex-specific organ transcriptional divergence without physiological differences in a murine model of fecal-induced peritonitis

2026-02-19

Abstract excerpt

<h4>ABSTRACT</h4> Sepsis is defined as a dysregulated response to infection, leading to life-threatening organ dysfunction that particularly affects parenchymal organs. Clinical studies remain inconclusive regarding the impact of biological sex on sepsis, and preclinical studies are predominantly performed in male animals. We examined early (8 h) septic responses in male and female mice using a fecal-induced peri...

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Literature Corpus work: c0549b90-1e7e-586c-a906-5021e8f542b4
DOI: 10.64898/2026.02.18.706550

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