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Article

Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection.

Scientific reports - 6 Nov 2013

Shimizu Akihisa, Kawana-Tachikawa Ai, Yamagata Atsushi, Han Chungyong, Zhu Dayong, Sato Yusuke, Nakamura Hitomi, Koibuchi Tomohiko, Carlson Jonathan, Martin Eric, Brumme Chanson J, Shi Yi, Gao George F, Brumme Zabrina L, Fukai Shuya, Iwamoto Aikichi

Abstract excerpt

We investigated the crystal structure of an HLA-A*2402-restricted CTL epitope in the HIV-1 nef gene (Nef134-10) before (pHLA) or after TCR docking. The wild type epitope and two escape mutants were included in the study. Y135F was an early-appearing major mutation, while F139L was a late-appearing mutation which was selected in the patients without Y135F. F139 was an eminent feature of the Nef134-10 epitope. Wild...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to nef Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 24192765
DOI: 10.1038/srep03097
PMCID: PMC3818656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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