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Article

A single residue exchange between two HLA-B27 alleles triggers increased peptide flexibility.

European biophysics journal : EBJ - 1 Nov 2004

Starikov Ewgeni B, Starikow Ewgeni B, Nilsson Lennart, Hülsmeyer Martin

Abstract excerpt

For more than 30 years, human leukocyte antigen B27 (HLA-B27) has been known to be closely related to the autoimmune disease ankylosing spondylitis, yet little is known about the molecular mechanisms of pathogenesis. Crystal structures of two closely related, but differently disease-associated, subtypes (B*2705 and B*2709) also did not resolve this situation as they revealed the bound nonapeptide in essentially...

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PMID: 15014909
DOI: 10.1007/s00249-004-0390-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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