The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.

doi:10.1002/emmm.200900026

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Article

The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.

EMBO molecular medicine - 1 Jul 2009

Yanagida Kanta, Okochi Masayasu, Tagami Shinji, Nakayama Taisuke, Kodama Takashi S, Nishitomi Kouhei, Jiang Jingwei, Mori Kohji, Tatsumi Shin-Ichi, Arai Tetsuaki, Ikeuchi Takeshi, Kasuga Kensaku, Tokuda Takahiko, Kondo Masaki, Ikeda Masaki, Deguchi Kentaro, Kazui Hiroaki, Tanaka Toshihisa, Morihara Takashi, Hashimoto Ryota, Kudo Takashi, Steiner Harald, Haass Christian, Tsuchiya Kuniaki, Akiyama Haruhiko, Kuwano Ryozo, Takeda Masatoshi

Abstract excerpt

Surrogate markers for the Alzheimer disease (AD)-associated 42-amino acid form of amyloid-beta (Abeta42) have been sought because they may aid in the diagnosis of AD and for clarification of disease pathogenesis. Here, we demonstrate that human cerebrospinal fluid (CSF) contains three APLP1-derived Abeta-like peptides (APL1beta) that are generated by beta- and gamma-cleavages at a concentration of approximately...

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PMID: 20049724
DOI: 10.1002/emmm.200900026
PMCID: PMC3378133

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APLP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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