Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cerebrospinal fluid biomarkers in Alzheimer's disease families with PSEN1 mutations.

Neuro-degenerative diseases - 1 Jan 2011

Fortea Juan, Lladó Albert, Bosch Beatriz, Antonell Anna, Oliva Rafael, Molinuevo Jose Luis, Sánchez-Valle Raquel

Abstract excerpt

BACKGROUND/AIMS: Familial Alzheimer's disease allows studies in the preclinical phases of the disease. We studied cerebrospinal fluid (CSF) amyloid β1-42 (Aβ1-42), total tau (t-tau) and phospho-tau181 (p-tau) levels in PSEN1 families and correlated the results with the genetic status, age and clinical stage. METHODS: Thirteen subjects from 3 families with 2 PSEN1 mutations (L286P, M139T) were recruited from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers

Share to Enzyme-Linked Immunosorbent Assay

Share to PSEN1 gene

Share to Mutation

Share to Presenilin-1

Share to tau Proteins

Source

Identifiers

PMID: 21212633
DOI: 10.1159/000322229

Genes

PSEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cerebrospinal fluid biomarkers in Alzheimer's disease families with PSEN1 mutations.PMID 21212633Read ↗

Cerebrospinal Fluid YKL-40 and Neurogranin in Familial Alzheimer's Disease: A Pilot Study.Semantic proximity Read ↗

Cerebrospinal Fluid Biomarkers in Familial Forms of Alzheimer's Disease and Frontotemporal Dementia.Semantic proximity Read ↗

Preclinical cerebrospinal fluid and volumetric magnetic resonance imaging biomarkers in Swedish familial Alzheimer's disease.Semantic proximity Read ↗

Associations of plasma biomarkers with age in the presenilin-1 E280A autosomal dominant Alzheimer's disease kindred.Semantic proximity Read ↗

Plasma biomarker profiles in autosomal dominant Alzheimer’s diseaseSemantic proximity Read ↗

Emerging Biomarkers for Early Detection of Alzheimer’s Disease: A Systematic ReviewSemantic proximity Read ↗

Consensus Report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease”Semantic proximity Read ↗

[Biomarkers in Alzheimer's disease].Semantic proximity Read ↗

Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease.Semantic proximity Read ↗

Autosomal Dominant Alzheimer Disease: A Unique Resource to Study CSF Biomarker Changes in Preclinical ADSemantic proximity Read ↗

Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset.Semantic proximity Read ↗

Cerebrospinal fluid levels of phosphorylated tau and Aβ1-38/Aβ1-40/Aβ1-42 in Alzheimer's disease with PS1 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.