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Article

Crucial parameters for precise copy number variation detection in formalin-fixed paraffin-embedded solid cancer samples.

Molecular oncology - 1 May 2026

Goris Hanne, Siozopoulou Vasiliki, van Kempen Léon C, Sieben Anne, Roelant Ella, Hellemans Stig, Backx Elyne, Sorber Laure, De Winne Koen, Koljenović Senada, Zwaenepoel Karen

Abstract excerpt

Copy number variations (CNVs) play a crucial role in cancer diagnostics and prognostics, potentially impacting treatment decisions. Ultra-low-pass whole-genome sequencing (ULP-WGS) has emerged as a promising alternative to array-based methods for CNV detection, especially in formalin-fixed paraffin-embedded (FFPE) samples. However, sequencing biases and sample heterogeneity necessitate the optimization of CNV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41437722
DOI: 10.1002/1878-0261.70192
PMCID: PMC13155139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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