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Article

Effect of genetic variants GSTA1 and CYP39A1 and age on busulfan clearance in pediatric patients undergoing hematopoietic stem cell transplantation.

Pharmacogenomics - 1 Nov 2013

ten Brink Marloes H, van Bavel Tom, Swen Jesse J, van der Straaten Tahar, Bredius Robbert G M, Lankester Arjan C, Zwaveling Juliëtte, Guchelaar Henk-Jan

Abstract excerpt

BACKGROUND: Busulfan is used in preparative regimens prior to stem cell transplantation in pediatric patients. There is significant interpatient variability in busulfan pharmacokinetics (PK) and exposure is related to outcome. To date, only polymorphisms in genes encoding for glutathione-S-transferases were studied, but could only explain a small portion of the variability in PK. AIM: To investigate the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24192117
DOI: 10.2217/pgs.13.159

Genes

GSTA1
ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of genetic variants GSTA1 and CYP39A1 and age on busulfan clearance in pediatric patients undergoing hematopoietic stem cell transplantation.PMID 24192117Read ↗

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