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Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in <i>Enterococcus faecalis</i>

4 Nov 2013

Abstract excerpt

Virulence factor secretion and assembly occurs at spatially restricted foci in some Gram-positive bacteria. Given the essentiality of the general secretion pathway in bacteria and the contribution of virulence factors to disease progression, the foci that coordinate these processes are attractive antimicrobial targets. In this study, we show in Enterococcus faecalis that SecA and Sortase A, required for the...

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PMID: 24191013
DOI: 10.1073/pnas.1319066110

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