Article
Thymic Nurse Cells Participate in Heterotypic Internalization and Repertoire Selection of Immature Thymocytes; Their Removal from the Thymus of Autoimmune Animals May be Important to Disease Etiology.
Current molecular medicine - 1 Jan 2015
Guyden J C, Martinez M, Chilukuri R V E, Reid V, Kelly F, Samms M-O D
Abstract excerpt
Thymic nurse cells (TNCs) are specialized epithelial cells that reside in the thymic cortex. The initial report of their discovery in 1980 showed TNCs to contain up to 200 thymocytes within specialized vacuoles in their cytoplasm. Much has been reported since that time to determine the function of this heterotypic internalization event that exists between TNCs and developing thymocytes. In this review, we discuss...
Topics
- Animals
- Autoimmune Diseases
- Autoimmunity
- Cell Communication
- Cell Differentiation
- Cell-in-Cell Formation
- Epithelial Cells
- Histocompatibility Antigens
- Humans
- Phenotype
- Thymocytes
- Thymus Gland