Article
Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability.
The Journal of biological chemistry - 13 Dec 2013
Fernández-Murray J Pedro, Ngo Michael H, McMaster Christopher R
Abstract excerpt
Choline is a precursor for the synthesis of phosphatidylcholine through the CDP-choline pathway. Saccharomyces cerevisiae expresses a single high affinity choline transporter at the plasma membrane, encoded by the HNM1 gene. We show that exposing cells to increasing levels of choline results in two different regulatory mechanisms impacting Hnm1 activity. Initial exposure to choline results in a rapid decrease in...
Topics
- Biological Transport, Active
- Choline
- Down-Regulation
- Endocytosis
- Endosomal Sorting Complexes Required for Transport
- Membrane Transport Proteins
- Mutation
- Phosphatidylcholines
- Protein Stability
- Protein Transport