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Article

Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals.

Cell metabolism - 6 Jun 2023

Kenny Timothy C, Khan Artem, Son Yeeun, Yue Lishu, Heissel Søren, Sharma Anurag, Pasolli H Amalia, Liu Yuyang, Gamazon Eric R, Alwaseem Hanan, Hite Richard K, Birsoy Kıvanç

Abstract excerpt

Genome-wide association studies (GWASs) of serum metabolites have the potential to uncover genes that influence human metabolism. Here, we combined an integrative genetic analysis that associates serum metabolites to membrane transporters with a coessentiality map of metabolic genes. This analysis revealed a connection between feline leukemia virus subgroup C cellular receptor 1 (FLVCR1) and phosphocholine, a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37100056
DOI: 10.1016/j.cmet.2023.04.003
PMCID: PMC10367582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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