Article
Unraveling the mode of action of the antimalarial choline analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae.
Antimicrobial agents and chemotherapy - 1 Aug 2004
Roggero Rodolphe, Zufferey Rachel, Minca Mihaela, Richier Eric, Calas Michele, Vial Henri, Ben Mamoun Choukri
Abstract excerpt
Pharmacological studies have indicated that the choline analog G25 is a potent inhibitor of Plasmodium falciparum growth in vitro and in vivo. Although choline transport has been suggested to be the target of G25, the exact mode of action of this compound is not known. Here we show that, similar to its effects on P. falciparum, G25 prevents choline entry into Saccharomyces cerevisiae cells and inhibits S....
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