Sensitivity to nitrogen mustard in Saccharomyces cerevisiae is independently determined by regulated choline permease and DNA repair.

doi:10.1016/0921-8777(94)90014-0

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Article

Sensitivity to nitrogen mustard in Saccharomyces cerevisiae is independently determined by regulated choline permease and DNA repair.

Mutation research - 1 Sept 1994

Li Z, Brendel M

Abstract excerpt

Sensitivity of yeast cells to the bifunctional alkylating agent nitrogen mustard (HN2) depends on two independently operating physiological mechanisms of cellular metabolism: dynamics of uptake of HN2 via choline permease, encoded in the gene HNM1/CTR, and repair of HN2-induced DNA damage. Uptake...

Topics

Biological Transport
Carrier Proteins
Choline
DNA Repair
DNA, Fungal
Fungal Proteins
Gene Expression Regulation, Fungal
Inositol
Mechlorethamine
Membrane Transport Proteins
Mutation
Promoter Regions, Genetic
Saccharomyces cerevisiae

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