Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitivity to nitrogen mustard in Saccharomyces cerevisiae is independently determined by regulated choline permease and DNA repair.

Mutation research - 1 Sept 1994

Li Z, Brendel M

Abstract excerpt

Sensitivity of yeast cells to the bifunctional alkylating agent nitrogen mustard (HN2) depends on two independently operating physiological mechanisms of cellular metabolism: dynamics of uptake of HN2 via choline permease, encoded in the gene HNM1/CTR, and repair of HN2-induced DNA damage. Uptake of choline and HN2 is impaired in mutant alleles of HNM1/CTR, leading to a HN2 hyper-resistant phenotype....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Carrier Proteins
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Fungal Proteins

Share to Mutation

Share to Promoter Regions, Genetic

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 7520996
DOI: 10.1016/0921-8777(94)90014-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitivity to nitrogen mustard in Saccharomyces cerevisiae is independently determined by regulated choline permease and DNA repair.PMID 7520996Read ↗

Hyper-resistance to nitrogen mustard in Saccharomyces cerevisiae is caused by defective choline transport.Semantic proximity Read ↗

A recessive mutant allele of the HNM1 gene of Saccharomyces cerevisiae is responsible for hyper-resistance to nitrogen mustard.Semantic proximity Read ↗

Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability.Semantic proximity Read ↗

Sensitivity to Sn2+ of the yeast Saccharomyces cerevisiae depends on general energy metabolism, metal transport, anti-oxidative defences, and DNA repair.Semantic proximity Read ↗

Global deletome profile of Saccharomyces cerevisiae exposed to lithium.Semantic proximity Read ↗

Reexamining the role of choline transporter-like (Ctlp) proteins in choline transport.Semantic proximity Read ↗

Selenium toxicity toward yeast as assessed by microarray analysis and deletion mutant library screen: a role for DNA repair.Semantic proximity Read ↗

The target of sodium toxicity in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations sensitizing yeast cells to the start inhibitor nalidixic acid.Semantic proximity Read ↗

HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The antifungal eugenol perturbs dual aromatic and branched-chain amino acid permeases in the cytoplasmic membrane of yeast.Semantic proximity Read ↗

A screening for high copy suppressors of the sit4 hal3 synthetically lethal phenotype reveals a role for the yeast Nha1 antiporter in cell cycle regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.