Article

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

2023-09-29

Abstract excerpt

Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and ethanolamine, respectively 1–6 . Despite the importance of these lipids, the mechanisms that enable the cellular uptake of choline and ethanolamine remain unknown. Here, we show that FLVCR1, whose mutation leads to the neurodegenerative syndrome...

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Literature Corpus work: 228b93ae-5b37-5cf0-882f-a42742cd17aa
DOI: 10.1101/2023.09.28.560019

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